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. 2021 Sep 10;13(18):4552. doi: 10.3390/cancers13184552

Figure 3.

Figure 3

Anti-IGFBP2 neutralizing antibody suppressed the CAF-like cell-induced migration and invasion in three esophageal squamous cell carcinoma (ESCC) cell lines. (A,B) Transwell migration (A) and invasion (B) assays of TE-8, TE-9, and TE-15 ESCC cell lines co-cultured with MSCs or CAF-like cells compared with those of monocultured ESCC cells. Migrating and invading cells on the bottom of the upper chamber were counted in five randomly selected fields. (C,D) Transwell migration (C) and invasion (D) assays of ESCC cell lines co-cultured with CAF-like cells and with the anti-IGFBP2 neutralizing antibody or control goat IgG antibody, compared with those without antibody. Migrating and invading cells on the bottom of the upper chamber were counted in five randomly selected fields. Data are presented as mean ± SEM (* p < 0.05, ** p < 0.01, *** p < 0.001, N.S. not significant).