Table 2.

Risk of Bias analysis of the included studies, according to the Cochrane Risk of Bias (RoB)-2 tool [32].

Study Name Author, Year [Ref]	Domain 1 Randomization Bias	Domain 2 Intervention Bias	Domain 3 Bias in Missing Outcome Data	Domain 4 Bias in Measurement of Outcome	Domain 5 Bias in Selection of the Reported Result	Overall Bias
GOG-0218 Tewari, 2018 [16]	Low risk	Low risk	Low risk	low risk	Low risk	Low risk
ICON-7 Perren, 2011 [17]	Low risk	Low risk	Low risk	low risk	Low risk	Low risk
ANTHALYA Joly, 2017 [33]	Some concerns	Some concerns	Low risk	Some concerns	Low risk	Some concerns
GEICO-1205 Garcia-Garcia, 2019 [34]	Some concerns	Some concerns	Low risk	Some concerns	Low risk	Some concerns
mEOC/GOG0421 Gore, 2019 [35]	Some concerns	Low risk	Low risk	low risk	Low risk	Low risk
Zhang, 2020 [36]	Some concerns	High risk	Low risk	High risk	Low risk	High risk
OCEANS Aghajanian, 2015 [20]	Low risk	Low risk	Low risk	low risk	Low risk	Low risk
GOG-0213 Coleman, 2017 [21]	Low risk	Low risk	Some concerns	Some concerns	Some concerns	Some concerns
MITO16B-MaNGO OV2B-ENGOT OV17 Pignata, 2021 [37]	Some concerns	Low risk	Low risk	Some concerns	Low risk	Some concerns
NSGO-AVANOVA2/ ENGOT-OV24 Mirza, 2019 [38]	Some concerns	Low risk	Low risk	Some concerns	Low risk	Some concerns
Cong, 2019 [39]	Some concerns	High risk	Low risk	High risk	Low risk	High risk
AURELIA Pujade-Lauraine, 2014 [22]	Some concerns	Low risk	Low risk	Some concerns	Low risk	Some concerns
Liu, 2019 [41]	Low risk	Some concerns	Low risk	Some concerns	Low risk	Some concerns
Zhang, 2019 [40]	Low risk	Some concerns	Low risk	Some concerns	Low risk	Some concerns