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Regulation of WAVE2 by several phosphorylation events: WRC is known as a signal integrator for sensing signals from Rac GTPases, phospholipids and protein kinases that sense growth factors and substrate adhesions. Cyclin-dependent kinase 1—CDK1, CDK5 and casein kinase 2 (CK2) are known to inhibit WAVE2 by keeping it in an inactive state whereas, AKT, ABI, Erk, PKA and PI3K (through VEGF) are known to release inactive WRC into an active WAVE2 complex.
