Table 3.
Adrenal glands and serum adrenaline and noradrenaline concentrations and liver, kidney, and heart lipidomics in rats of control (C), sepsis (S), and meldonium + sepsis (M + S) groups. All units are given as mg/kg tissue. FFAs abbreviations: myristic—C14:0; pentadecylic—C15:0; palmitic—C16:0; palmitoleic—C16:1; margaric—C17:0; stearic—C18:0; oleic/elaidic—C18:1 cis + trans; linoleic/linolelaidic—C18:2, cis + trans; arachidonic—C20:4; behenic—C22:0; erucic—C22:1; cervonic—C22:6. The number of animals per experimental group: n = 8. The data are given as mean ± standard error of the mean. Minimal significance level: p < 0.05. Significantly different: a in respect to the C group; b in respect to the S group.
| Adrenal Glands | C Group | S Group | M + S Group |
| Adrenaline | 100 ± 4.945 | 60.586 ± 2.946 a | 29.058 ± 0.964 a,b |
| Noradrenaline | 100 ± 3.221 | 98.356 ± 2.389 | 83.698 ± 3.232 a,b |
| Serum | C group | S group | M + S group |
| Adrenaline | 1651.983 ± 66.585 | 1238.067 ± 53.207 a | 1354.9 ± 17.081 a |
| Noradrenaline | 1297.667 ± 21.243 | 1475.2 ± 24.198 a | 957.233 ± 46.875 a,b |
| Liver | C group | S group | M + S group |
| L carnitine | 6.600 ± 0.024 | 17.256 ± 0.922 a | 4.631 ± 0.052 a,b |
| Glycerol | 0.071 ± 0.001 | 1.231 ± 0.019 a | 0.879 ± 0.014 a,b |
| Triglycerides | 1.372 ± 0.085 | 5.750 ± 0.078 a | 2.052 ± 0.070 a,b |
| Glucose | 2.353 ± 0.021 | 3.459 ± 0.045 a | 2.588 ± 0.024 b |
| Lactate | 1.936 ± 0.011 | 4.194 ± 0.146 a | 2.469 ± 0.017 a,b |
| Fructose | 0.024 ± 0.001 | 0.888 ± 0.006 a | 0.081 ± 0.001 a,b |
| Sucrose | 0.021 ± 0.001 | 0.108 ± 0.005 a | 0.061 ± 0.001 a,b |
| C14:0 | 8.333 ± 0.078 | 13.358 ± 0.400 a | 6.393 ± 0.062 a,b |
| C15:0 | 6.363 ± 0.041 | 11.768 ± 0.326 a | 7.248 ± 0.029 b |
| C16:0 | 5.145 ± 0.024 | 10.205 ± 0.304 a | 4.681 ± 0.034 b |
| C16:1 | 0.461 ± 0.011 | 0.650 ± 0.009 a | 0.307 ± 0.012 a,b |
| C17:0 | 0.346 ± 0.036 | 0.723 ± 0.003 a | 0.309 ± 0.012 b |
| C18:0 | 5.121 ± 0.008 | 12.429 ± 0.127 a | 4.779 ± 0.032 b |
| C18:1, c + t | 2.175 ± 0.025 | 3.030 ± 0.024 a | 1.519 ± 0.030 a,b |
| C18:2, c + t | 5.013 ± 0.043 | 9.461 ± 0.145 a | 4.265 ± 0.027 b |
| C20:4 | 5.484 ± 0.112 | 12.267 ± 0.122 a | 5.633 ± 0.093 b |
| C22:0 | 1.505 ± 0.037 | 1.340 ± 0.056 a | 0.832 ± 0.010 a,b |
| C22:1 | 0.230 ± 0.008 | 0.395 ± 0.027 a | 0.313 ± 0.007 a,b |
| C22:6 | 0.825 ± 0.005 | 1.565 ± 0.104 a | 0.845 ± 0.012 b |
| The FFAs sum | 40.951 ± 0.263 | 77.189 ± 0.917 a | 37.124 ± 0.191 b |
| Kidney | C group | S group | M + S group |
| L carnitine | 1.757 ± 0.017 | 8.512 ± 0.664 a | 1.551 ± 0.179 b |
| Glycerol | 0.372 ± 0.007 | 0.671 ± 0.018 a | 0.317 ± 0.015 b |
| Triglycerides | 1.624 ± 0.049 | 1.107 ± 0.013 a | 1.278 ± 0.022 a |
| Glucose | 1.275 ± 0.007 | 3.309 ± 0.098 a | 0.700 ± 0.012 a,b |
| Lactate | 1.932 ± 0.128 | 3.473 ± 0.179 a | 2.719 ± 0.158 a,b |
| Fructose | 0.117 ± 0.055 | 0.573 ± 0.113 a | 0.104 ± 0.056 b |
| Sucrose | 0.051 ± 0.001 | 0.103 ± 0.010 a | 0.060 ± 0.001 b |
| C14:0 | 6.054 ± 0.123 | 37.325 ± 1.935 a | 16.685 ± 0.260 a,b |
| C15:0 | 82.960 ± 2.172 | 3.288 ± 0.861 a | 0.127 ± 0.006 a,b |
| C16:0 | 39.500 ± 1.617 | 489.563 ± 25.487 a | 143.866 ± 3.856 a,b |
| C16:1 | 56.845 ± 1.250 | 11.740 ± 0.928 | 0.095 ± 0.002 a,b |
| C17:0 | 59.144 ± 1.534 | 24.153 ± 3.155 a | 0.098 ± 0.002 a,b |
| C18:0 | 44.908 ± 1.154 | 172.758 ± 17.153 a | 50.237 ± 1.445 b |
| C18:1 cis + trans | 18.642 ± 0.852 | 103.390 ± 14.797 a | 0.260 ± 0.011 a,b |
| C18:2 cis + trans | 24.550 ± 0.601 | 82.404 ± 14.128 a | 20.061 ± 0.664 b |
| C20:4 | 46.280 ± 1.108 | 0.499 ± 0.0267 a | 0.523 ± 0.025 a |
| C22:0 | 20.489 ± 0.699 | 0.825 ± 0.105 a | 0.836 ± 0.018 a |
| C22:1 | 26.175 ± 1.109 | 7.219 ± 0.315 a | 11.429 ± 0.483 a,b |
| C22:6 | 17.587 ± 1.102 | 5.534 ± 0.295 a | 13.175 ± 0.481 b |
| The FFAs sum | 443.134 ± 11.702 | 938.697 ± 66.007 a | 257.395 ± 4.710 a,b |
| Heart | C group | S group | M + S group |
| L carnitine | 0.990 ± 0.012 | 3.976 ± 0.042 a | 0.760 ± 0.008 b |
| Glycerol | 0.074 ± 0.018 | 0.307 ± 0.014 a | 0.088 ± 0.011 b |
| Triglycerides | 0.856 ± 0.033 | 1.959 ± 0.024 a | 0.952 ± 0.017 b |
| Glucose | 0.793 ± 0.006 | 0.554 ± 0.005 a | 0.129 ± 0.002 a,b |
| Lactate | 0.309 ± 0.001 | 1.316 ± 0.014 a | 0.305 ± 0.001 b |
| Fructose | 0.012 ± 0.001 | 0.012 ± 0.001 | 0.0085 ± 0.0001 a,b |
| Sucrose | 0.0012 ± 0.0001 | 0.0065 ± 0.0002 a | 0.0041 ± 0.0001 a,b |
| C14:0 | 7.194 ± 0.074 | 25.342 ± 0.874 a | 11.539 ± 0.130 a,b |
| C15:0 | 44.661 ± 1.097 | 7.528 ± 0.409 a | 3.688 ± 0.0142 a,b |
| C16:0 | 22.322 ± 0.809 | 249.884 ± 12.715 a | 74.273 ± 1.922 a,b |
| C16:1 | 28.653 ± 0.626 | 6.195 ± 0.462 a | 0.201 ± 0.005 a,b |
| C17:0 | 29.745 ± 0.774 | 12.438 ± 1.578 a | 0.204 ± 0.006 a,b |
| C18:0 | 25.015 ± 0.580 | 92.593 ± 8.586 a | 27.508 ± 0.718 b |
| C18:1 cis + trans | 10.408 ± 0.421 | 53.210 ± 7.404 a | 0.890 ± 0.014 a,b |
| C18:2 cis + trans | 14.782 ± 0.290 | 45.933 ± 7.043 a | 12.163 ± 0.324 b |
| C20:4 | 25.882 ± 0.558 | 6.383 ± 0.056 a | 3.078 ± 0.041 a,b |
| C22:0 | 10.997 ± 0.357 | 1.083 ± 0.044 a | 0.835 ± 0.008 a |
| C22:1 | 13.202 ± 0.557 | 3.807 ± 0.150 a | 5.871 ± 0.239 a,b |
| C22:6 | 9.205 ± 0.550 | 3.549 ± 0.144 a | 7.010 ± 0.241 a,b |
| The FFAs sum | 242.067 ± 5.894 | 507.943 ± 32.945 a | 147.260 ± 2.356 a,b |