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. 2021 Sep 20;26(18):5688. doi: 10.3390/molecules26185688

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Scheme 1 — Reagents and conditions: (a) AcOH, 100 °C, 30 min, 35–90%; (b) CDI, MeONa, dimethylformamide, 25 °C, 1 h, 80%; (c) NBS, CCl₄, 90 °C, 2 h, 80%; (d) R₂NH; THF; 25 °C, 25–30%; (e) NH₂OH∙HCl, C₅H₅N, EtOH, 100 °C, 4 h, 90–95%; (f) NH₂OH∙HCl, NaOH, 80 °C, 2 h, 90–95%. Abbreviations: MRF—morpholin-1-yl.