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. 2021 Sep 20;26(18):5688. doi: 10.3390/molecules26185688

Table 1.

Chemical structure and activity of previously identified JNK1-3 inhibitors with an 11H-indeno[1,2-b]quinoxalin-11-one scaffold containing different substituents in the tetracyclic moiety [35,36].

graphic file with name molecules-26-05688-i001.jpg graphic file with name molecules-26-05688-i002.jpg
             Compound C
R1 R2 R3 Kd (µM)
JNK1 JNK2 JNK3
IQ-1 H H H 0.2 0.4 0.1
A H H COOH 2.1 6.0 3.9
B H NO2 H 6.0 12.0 4.3
C H H Cl 1.1 21.5 0.7
D H CH3 H 0.7 0.8 0.3
E H OC2H5 H 2.3 2.0 0.9
F CH3 H H 3.3 2.5 6.0
G H CH3 CH3 2.7 2.5 1.3