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. 2021 Sep 20;26(18):5688. doi: 10.3390/molecules26185688

Table 3.

Chemical structures of synthesized oxime derivatives and JNK binding affinity.

graphic file with name molecules-26-05688-i003.jpg

Compound R1 R2 R3 JNK1 JNK2 JNK3
Kd (µM)
IQ-1 * H H H 0.24 0.36 0.10
4a H F H 0.28 ± 0.07 0.62 ± 0.01 0.19 ± 0.01
4b Cl H H 0.17 ± 0.04 0.22 ± 0.06 0.14 ± 0.03
4c CH3 H Br N.B. N.B. N.B.
4d H t-Bu H 3.1 ± 0.1 1.6 ± 0.6 3.1 ± 0.2
4e F H F 0.92 ± 0.05 1.6 ± 0.01 0.9 ± 0.3
4f H F F 0.17 ± 0.04 N.B. 0.52 ± 0.3
4g F F H 0.52 ± 0.09 0.91 ± 0.06 1.1 ± 0.1
4h Br H CF3 N.B. N.B. N.B.
4i Cl H CF3 N.B. N.B. N.B.
4j CF3 H CF3 N.B. N.B. N.B.
4k H F Cl N.B. N.B. 24.5 ± 2.1
4l H H COOCH3 0.91 ± 0.16 2.4 ± 0.2 0.71 ± 0.05
4m CH2MRF H H 1.1 ± 0.1 0.88 ± 0.10 0.91 ± 0.3

* Data for IQ-1 are from [35]. N.B., no binding affinity at concentrations < 30 μM. Abbreviations: MRF, morpholine.