Table 5.

Antinociceptive activities and gastrointestinal transit inhibition by N-methylmorphinan-6-ones 2, 3 and 13 and morphine.

	Antinociception a (AD50 nmol/kg, s.c.)	Gastrointestinal Transit b (EC50 nmol/kg, s.c.)
2	53	37
3	9.6	27 c
13	0.70	1.70
Morphine	6690	3800 7622 c

^a Determined in the hot-plate test in mice after s.c. administration. ^b Determined in the charcoal test in mice after s.c. administration. ^c Determined in the colonic bead expulsion test in mice after s.c. administration. Data from [89,91]. For compound structures, refer to Scheme 1 and Scheme 6.