. 2021 Sep 18;26(18):5677. doi: 10.3390/molecules26185677

Table 7.

Antinociceptive potencies of differently 5-substituted N-methylmorphinan-6-ones 2, 4, 17 and 21.

	ED₅₀ (µg/kg, s.c.) ^a
	Hot-Plate Test	Tail-Flick Test	PPQ Abdominal Stretching Test
2	17	14	- ^b
4	30	30	9.0
17	0.10	0.08	0.16
21	53	43	-
Morphine	850	1920	400

^a Determined in mice after s.c. administration. ^b not determined. Data from [90,102]. For compound structures, refer to Scheme 1, Scheme 7 and Scheme 8.