Table 4.
List of genes with identified gene variants.
| Gene Symbol | HGVSg | ALT | Consequence | Amino Acids | Existing VARIATION | Impact | PolyPhen | ADHD with/without QV for Gene | non-ADHD with/without QV for Gene | P-Value Fisher Exact Test |
|---|---|---|---|---|---|---|---|---|---|---|
| (A) Detected Gene Variants in ADHD vs. Not Detect in Non-ADHD | ||||||||||
| ADRA2A | chr10:g.111078090G>C | C | MV | E/Q | rs753177273,COSV54528494 | M | benign | 2/47 | 0/46 | 0.263 |
| ADRA2A | chr10:g.111078097C>A | A * | MV | P/Q | - | M | probably damaging | |||
| DBH | chr9:g.133656524G>C | C * | MV, SRV | G/A | COSV67548769 | M | probably damaging | 1/48 | 0/46 | 0.516 |
| DYNC1H1 | chr14:g.102016033G>A | A | MV | A/T | rs766837403,COSV64136626 | M | benign | 1/48 | 0/46 | 0.516 |
| FBXL17 | chr5:g.108224144T>C | C | MV | K/E | rs141165823 | M | benign | 5/44 | 0/46 | 0.033 |
| FBXL17 | chr5:g.108380944C>A | A * | MV | A/S | - | M | benign | |||
| FBXL17 | chr5:g.108380956C>A | A * | MV | G/C | - | M | possibly damaging | |||
| FBXL17 | chr5:g.108381031_108381033dup | ACCG * | II | G/GG | rs906102490 | M | - | |||
| MAP1A | chr15:g.43527328A>C | C * | MV | E/A | - | M | probably damaging | 1/48 | 0/46 | 0.516 |
| MTHFR | chr1:g.11794399_11794400insAAA | CAAA * | II | -/F | - | M | - | 1/48 | 0/46 | 0.516 |
| PCDH7 | chr4:g.30721475G>T | T | MV | C/F | rs757643187 | M | benign | 1/48 | 0/46 | 0.516 |
| RSPH3 | chr6:g.158999732A>C | C * | MV | I/R | rs1217221445 | M | benign | 1/48 | 0/46 | 0.516 |
| SCN2A | chr2:g.165307860G>A | A * | MV | M/I | COSV51836794 | M | probably damaging | 1/48 | 0/46 | 0.516 |
| SEMA6D | chr15:g.47771337G>A | A | MV | R/Q | rs766660850 | M | probably damaging | 2/47 | 0/46 | 0.263 |
| SEMA6D | chr15:g.47771766T>C | C * | MV | L/P | rs540588380 | M | possibly damaging | |||
| SPTBN1 | chr2:g.54599190C>G | G * | MV | R/G | rs915376910,COSV61693274 | M | probably damaging | 1/48 | 0/46 | 0.516 |
| TNRC6C | chr17:g.78091580C>T | T * | MV | P/S | rs1302015314 | M | benign | 1/48 | 0/46 | 0.516 |
| ZNF536 | chr19:g.30548324_30548326del | A * | ID | RA/T | - | M | - | 2/47 | 0/46 | 0.263 |
| ZNF536 | chr19:g.30549475A>C | C * | MV | T/P | rs1257346923 | M | benign | |||
| (B) Detected Gene Variants in ADHD with EBW vs. Not Detect in Non-ADHD with NBW | ||||||||||
| ADRA2A | chr10:g.111078090G>C | C | MV | E/Q | rs753177273,COSV54528494 | M | benign | 1/13 | 0/44 | 0.241 |
| DYNC1H1 | chr14:g.102016033G>A | A | MV | A/T | rs766837403,COSV64136626 | M | benign | 1/13 | 0/44 | 0.241 |
| FTO | chr16:g.53826140G>A | A | MV | A/T | rs79206939 | M | benign | 1/13 | 0/44 | 0.241 |
| MAP1A | chr15:g.43527328A>C | C * | MV | E/A | - | M | probably damaging | 1/13 | 0/44 | 0.241 |
| SEMA6D | chr15:g.47771337G>A | A | MV | R/Q | rs766660850 | M | probably damaging | 1/13 | 0/44 | 0.241 |
| ZNF536 | chr19:g.30549475A>C | C * | MV | T/P | rs1257346923 | M | benign | 1/13 | 0/44 | 0.241 |
Rare variants with frequency: 0.009%, * very rare variant with frequency: 0.0009%, HGVSg—Human Genome Variation Society genomic nomenclature; ALT—Alternative variant; PolyPhen—Polymorphism Phenotyping (prediction of functional effects of human nsSNP and prediction of possible impact of an amino acid substitution on the structure and function of a human protein using straightforward physical and comparative considerations); QV—Qualifying variants; M—Moderate; MV—Missense Variant; II—Inframe Insertion; ID—Inframe Deletion; SRV—Splice Region Variant; EBW—Excessive Body Weight; NBW—Normal Body Weight; in bold—significant effect with p < 0.05.