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Mechanism of immune escape induced by AnxA1 in the TME. AnxA1 expressed by cancer cells promotes the expansion of Tregs, tDCs and TH17. Moreover, AnxA1 can activate FPR2 on the cell surface of macrophages, supporting the polarization toward an M2 phenotype. In turn, M2 macrophages induce MDSC activity and inhibit the maturation of DCs by producing IL-10.
