Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Mechanisms of immune escape mediated by the AnxA1/EGFR interaction. AnxA1 interacts with EGFR (1) and promotes its internalization (2 and 3) and its retrograde transport to nuclei (4 and 5). Once in nuclei, EGFR interacts with STAT3 and induces the expression of PD-L1 (6), thus resulting in immune suppression.
