Table A2.
Average concentration values of groups for bile acid metabolites.
| Control | IBS-C | FC | IBS-D | FD | IBS-M | |
|---|---|---|---|---|---|---|
| GHDCA | 0.72 ± 3.61 | 0.29 ± 0.56 | 0.21 ± 0.26 | 0.34 ± 0.31 | 0.40 ± 0.49 | 0.24 ± 0.24 |
| GUDCA | 0.81 ± 3.88 | 0.32 ± 0.57 | 0.47 ± 1.26 | 0.40 ± 0.38 | 0.47 ± 0.58 | 0.28 ± 0.25 |
| GDCA | 110.41 ± 167.88 | 53.49 ± 54.29 | 126.42 ± 371.25 | 119.12 ± 130.64 | 91.47 ± 88.84 | 92.10 ± 112.37 |
| HDCA | 90.55 ± 101.77 | 92.99 ± 96.97 | 87.33 ± 77.63 | 122.15 ± 135.87 | 84.13 ± 88.98 | 71.12 ± 71.11 |
| HCA | 6.77 ± 13.63 | 2.26 ± 1.97 | 3.43 ± 3.87 | 5.62 ± 6.66 | 9.87 ± 21.42 | 5.21 ± 7.40 |
| GCA | 199.35 ± 317.56 | 68.1 ± 86.16 | 118.23 ± 222.78 | 221.83 ± 346.59 | 177.95 ± 169.83 | 166.30 ± 353.11 |
| ILA | 31.51 ± 20.67 | 30.91 ± 18.1 | 31.25 ± 17.92 | 33.17 ± 23.27 | 28.97 ± 15.79 | 35.01 ± 22.27 |
| GLCA | 0.18 ± 0.18 | 0.17 ± 0.13 | 0.21 ± 0.21 | 0.20 ± 0.15 | 2.01 ± 6.22 | 0.16 ± 0.11 |
| Taurine | 5.56 ± 18.91 | 4.65 ± 18.29 | 7.29 ± 23.0 | 17.85 ± 46.93 | 16.59 ± 29.4 | 1.84 ± 4.07 |
| LCA | 548.75 ± 336.88 | 483.52 ± 270.23 | 481.59 ± 271.46 | 618.36 ± 426.56 | 451.99 ± 189.5 | 513.83 ± 289.08 |
| CDCA | 29.65 ± 102.48 | 9.31 ± 15.35 | 11.61 ± 23.37 | 31.92 ± 67.42 | 32.39 ± 70.86 | 22.83 ± 50.26 |
| CA | 56.16 ± 255.46 | 12.44 ± 23.53 | 11.16 ± 30.87 | 58.79 ± 172.97 | 160.13 ± 513.21 | 37.52 ± 99.60 |
| TLCA | 0.94 ± 4.46 | 0.26 ± 0.77 | 0.35 ± 0.8 | 1.69 ± 6.10 | 2.17 ± 3.82 | 0.76 ± 3.06 |
| TCDCA | 3.35 ± 10.5 | 1.19 ± 2.48 | 4.65 ± 14.37 | 6.35 ± 19.67 | 7.28 ± 12.12 | 3.30 ± 8.97 |
| TDCA | 4.84 ± 12.5 | 0.64 ± 0.68 | 2.27 ± 6.24 | 3.54 ± 11.74 | 5.34 ± 5.89 | 3.26 ± 10.22 |
| TCA | 4.14 ± 7.82 | 2.06 ± 3.1 | 2.10 ± 4.87 | 6.47 ± 20.76 | 2.70 ± 4.0 | 6.55 ± 28.14 |
Values presented as mean (µg/mg) ± standard deviation. Abbreviations: Healthy control (control), functional constipation (FC), IBS-constipation (IBS-C), functional diarrhea (FD), IBS-diarrhea (IBS-D), IBS-mixed (IBS-M). Cholic acid (CA); chenodeoxycholic acid (CDCA); glyco-hyo-deoxycholic acid (GHDCA); glyco-urso-deoxycholic acid (GUDCA); glyco-deoxycholic acid (GDCA); hyo-deoxycholic acid (HDCA); hyo-cholic acid (HCA); glyco-cholic acid (GCA); iso-lithocholic acid (ILA); glyco-litho cholic acid (GLCA); lithocholic acid (LCA); tauro-lithocholic acid (TLCA); tauro-cheno-deoxycholic acid (TCDCA); tauro-deoxycholic acid (TDCA); tauro-cholic acid (TCA).