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. 2021 Sep 15;22(18):9973. doi: 10.3390/ijms22189973

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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DN (CD4-CD8-)T-cell response to SEB stimulation in healthy individuals stratified by CMV serostatus and age. (A) Percentage of DN T-cells that have any studied response to SEB, either total degranulation (CD107a) or the production of either of the cytokines, IFN-γ or TNF-α. (B) Graph shows the Boolean analysis result of SEB-induced responses (CD107a, IFN-γ, and/or TNF-α). Scatter graphs show the magnitude of SEB responses within each functional category, expressed as percentage of DN T-cells. The combination of functions studied is indicated in the table below the scatter graphs. (C) Polyfunctionality index (PI) of DN T-cells in all groups in response to SEB. (D) PI of DN T-cells according to CD57 expression. Horizontal black lines indicate interquartile ranges, ranging from the 25th to the 75th percentile. The median for DN T-cells SEB-induced responses is indicated by the bars´ upper limit. Results were considered significant at * p < 0.05, ** p < 0.01, and *** p < 0.001.