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GR post-translational modifications: impact on receptor’s function. GR is subjected to a variety of posttranslational modifications (PTMs), which have a major impact on receptor function. Scheme indicates PTM target residues for hGRα including phosphorylation (P), acetylation (A), ubiquitination (U), SUMOylation (S), and oxidation (O). The major kinases phosphorylating GR and the outcome of the corresponding PTMs are also indicated (green, activation; salmon, inhibition).
