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. 2021 Aug 30;11(9):902. doi: 10.3390/life11090902

Figure 4.

Figure 4

Effect of aspirin (ASA) on the activities of mitochondrial complexes and ATP levels in the pancreas and heart of control Wistar and GK rats (n = 5). Mitochondrial respiratory enzyme Complexes I (A), II/III (B) and IV (C) activities were measured in freshly prepared mitochondrial fractions from the pancreas and heart of control Wistar and GK rats using enzyme-specific substrates, as described in the Materials and Methods. The ATP content (D) in the rat tissues was determined using the ATP Bioluminescent cell assay kit (Sigma, St. Louis, MO, USA). Results are expressed as mean + SD from three independent experiments and asterisks indicate a significant difference. * p < 0.05 compared to control, ** p < 0.001 compared to control, ∆ p < 0.05 compared to GK, ∆∆ p < 0.001 compared to GK rats.