Table 3.
Multivariate Cox regression analysis for survival.
| Variables | PFS | OS | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | p * | HR | 95% CI | p * | |
| All patients | ||||||
| Age (≥60 years vs. <60 years) | 1.38 | 0.51–3.72 | 0.52 | 1.35 | 0.54–3.33 | 0.52 |
| Resection degree (low vs. high) | 2.03 | 0.95–4.35 | 0.0683 | 3.72 | 1.60–8.64 | 0.0023 |
| RPA (≥V vs. <V) | 1.97 | 0.80–4.86 | 0.14 | 1.43 | 0.61–3.35 | 0.42 |
| MGMT (Un-Methylated vs. Methylated) | 4.71 | 1.43–8.93 | 0.0065 | 4.71 | 1.85–11.90 | 0.0011 |
| Integrin α5 (high vs. low) | 1.28 | 0.57–2.88 | 0.55 | 1.11 | 0.51–2.40 | 0.79 |
| Stupp | ||||||
| Age (≥60 years vs. <60 years) | 1.28 | 0.45–3.69 | 0.64 | 1.31 | 0.48–3.60 | 0.58 |
| Resection degree (low vs. high) | 1.87 | 0.86–4.07 | 0.12 | 3.73 | 1.52–9.16 | 0.0040 |
| RPA (≥V vs. <V) | 1.83 | 0.69–4.88 | 0.22 | 1.71 | 0.45–3.07 | 0.75 |
| MGMT (Un-Methylated vs. Methylated) | 4.46 | 1.68–11.84 | 0.0027 | 6.95 | 2.45–19.72 | 0.0002 |
| Integrin α5 (high vs. low) | 1.28 | 0.55–3.01 | 0.57 | 1.22 | 0.51–2.91 | 0.66 |
| Completed Stupp | ||||||
| Age (≥60 years vs. <60 years) | 2.48 | 0.61–10.09 | 0.20 | 2.20 | 0.53–9.09 | 0.27 |
| Resection degree (low vs. high) | 1.41 | 0.54–3.68 | 0.48 | 2.04 | 0.60–6.90 | 0.25 |
| RPA (≥V vs. <V) | 1.16 | 0.31–4.28 | 0.83 | 3.12 | 0.73–13.25 | 0.12 |
| MGMT (Un-Methylated vs. Methylated) | 2.58 | 0.76–8.76 | 0.128 | 4.27 | 1.08–16.83 | 0.038 |
| Integrin α5 (high vs. low) | 2.09 | 0.63–6.90 | 0.22 | 4.77 | 1.17–19.44 | 0.029 |
PFS: progression-free survival; OS: overall survival; HR: hazard ratio; 95% CI: 95% confidence interval; y: year; RPA: recursive partitioning analysis; MGMT: O-6-methylguanine-DNA methyltransferase. * multivariate COX regression analysis, p < 0.05 was considered as significant.