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. 2021 Sep 11;10(9):2389. doi: 10.3390/cells10092389

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Functional annotation enrichment analysis of the whole-transcriptomes profile using Database for Annotation, Visualization and Integrated Discovery (DAVID). (A) Genes were categorized by gene set enrichment analysis according to age and pregnancy. Enrichment map test p-values, p < 0.001 to >0.05. Data are presented as means ± SEM of three replicates. Significant differences are indicated by asterisks (* p < 0.05). (B) Schematic of cumulus cell signaling pathway involving up- and downregulated genes, based on the ovarian steroidogenesis KEGG pathway map from the gene set enrichment analysis.

Functional annotation enrichment analysis of the whole-transcriptomes profile using Database for Annotation, Visualization and Integrated Discovery (DAVID). (A) Genes were categorized by gene set enrichment analysis according to age and pregnancy. Enrichment map test p-values, p < 0.001 to >0.05. Data are presented as means ± SEM of three replicates. Significant differences are indicated by asterisks (* p < 0.05). (B) Schematic of cumulus cell signaling pathway involving up- and downregulated genes, based on the ovarian steroidogenesis KEGG pathway map from the gene set enrichment analysis.