Table 1.
Patients’ characteristics and oocyte profiling of women in the young and old groups, with or without pregnancy. BL: blastocyst, CL: cleavage stage embryo. Significant differences are indicated by asterisks (* p < 0.05).
| Young Preg (n = 8) |
Young Non-Preg (n = 8) |
Old Preg (n = 8) |
Old Non-Preg (n = 8) |
|
|---|---|---|---|---|
| Age (years) | 31.16 ± 1.16 | 33.8 ± 1.78 | 39.83 ± 0.75 | 40.83 ± 1.83 |
| Serum AMH (ng/mL) | 4.49 ± 2.79 | 2.80 ± 1.27 | 1.95 ± 1.01 | 1.99 ± 0.97 |
| BMI (kg/m2) | 23.30 ± 3.41 | 21.49 ± 2.56 | 24.20 ± 3.15 | 22.33 ± 2.56 |
| Basal FSH (mIU/mL) | 7.96 ± 2.99 | 8.36 ± 2.20 | 8.23 ± 2.16 | 7.89 ± 1.47 |
| No. of previous IVF cycles | 2.6 ± 1.67 | 2.0 ± 1.22 | 1.0 ± 0.81 | 2.16 ± 1.60 |
| Total Gonadotropin dose | 3030 ± 497 | 2308 ± 820 | 2525 ± 318 | 2995 ± 359 |
| No. of antral follicle count | 11.25 ± 5.31 | 8.88 ± 7.64 | 8.80 ± 3.63 | 9.33 ± 4.96 |
| No. of retrieved oocytes | 13.16 ± 6.43 | 10.4 ± 2.30 | 8.66 ± 5.88 | 10.16 ± 4.99 |
| Maturation rate (%) | 77.01 ± 15.31 * | 64.77 ± 7.08 | 87.12 ± 16.11 * | 81.22 ± 17.78 |
| No. of MII oocytes | 9.5 ± 3.93 | 6.8 ± 2.04 | 5.0 ± 3.37 | 6.66 ± 4.84 |
| Fertilization rate (%) | 91.05 ± 8.61 | 68.85 ± 32.23 | 83.33 ± 23.57 | 75.82 ± 17.93 |
| No. of transferred embryo | 1.16 ± 0.40 | 1.63 ± 0.92 | 2.33 ± 0.81 | 2.00 ± 0.00 |
| Stage of transferred embryo | ||||
| BL (%)/CL (%) | 100 */0 | 62.5/37.5 | 83.33 */16.67 | 66.66/33.33 |
Hierarchical clustering and MDS (multidimensional scaling) of transcriptome profiling in the CCs.