Table 4.
The statistically significant DEGs in the hypothalamus of tame versus aggressive rats bred artificially during 90 generations from the same common ancestral subpopulation.
| Rat Gene | Differential Expression | ||||
|---|---|---|---|---|---|
| No. | Symbol | Name | log2 | p | PADJ |
| 1 | Ascl3 | achaete-scute family bHLH transcription factor 3 | 3.99 | 10−12 | 10−8 |
| 2 | Morn1 | MORN repeat containing 1 | 1.24 | 10−10 | 10−6 |
| 3 | Krt2 | keratin 2 | −1.65 | 10−8 | 10−4 |
| 4 | Banp | Btg3 associated nuclear protein | −0.82 | 10−6 | 10−3 |
| 5 | Mre11 | MRE11 homolog, double strand break repair nuclease | −2.47 | 10−6 | 10−3 |
| 6 | Rbm3 | RNA binding motif protein 3 | 1.04 | 10−6 | 10−3 |
| 7 | Fcgr3a | Fc fragment of IgG receptor IIIa | 2.06 | 10−6 | 10−2 |
| 8 | Plac8 | placenta associated 8 (synonym: onzin) | 2.83 | 10−5 | 10−2 |
| 9 | Cd22 | CD22 molecule | 2.85 | 10−5 | 10−2 |
| 10 | Apobec1 | apolipoprotein B mRNA editing enzyme catalytic subunit 1 | 1.87 | 10−5 | 10−2 |
| 11 | Magee2 | MAGE family member E2 | −0.95 | 10−5 | 10−2 |
| 12 | Hbb-b1 | hemoglobin, β adult major chain | −3.97 | 10−5 | 10−2 |
| 13 | Tpm2 | tropomyosin 2 | 1.44 | 10−5 | 10−2 |
| 14 | Apobr | apolipoprotein B receptor | 1.56 | 10−5 | 10−2 |
| 15 | Cenps | centromere protein S | 1.63 | 10−4 | 0.05 |
| 16 | Gale | UDP-galactose-4-epimerase | 1.15 | 10−4 | 0.05 |
| 17 | Pcdhb9 | protocadherin β9 | −1.01 | 10−4 | 0.05 |
| 18 | P2rx4 | purinergic receptor P2X 4 | 1.14 | 10−4 | 0.05 |
| 19 | Rn45s | 45S pre-ribosomal RNA | −1.62 | 10−4 | 0.05 |
| 20 | Nr4a3 | nuclear receptor subfamily 4, group A, member 3 | −1.29 | 10−4 | 0.05 |
| 21 | Ghitm | growth hormone inducible transmembrane protein | 0.40 | 10−4 | 0.05 |
| 22 | Shox2 | short stature homeobox 2 | 6.18 | 10−4 | 0.05 |
| 23 | Insig1 | insulin induced gene 1 | 0.49 | 10−4 | 0.05 |
| 24 | Orai1 | ORAI calcium release-activated calcium modulator 1 | 1.83 | 10−4 | 0.05 |
| 25 | Thrsp | thyroid hormone responsive | 1.43 | 10−4 | 0.05 |
| 26 | Spint1 | serine peptidase inhibitor, Kunitz type 1 | −0.91 | 10−4 | 0.05 |
| 27 | Liph | lipase H | 3.28 | 10−4 | 0.05 |
| 28 | Pla2g2c | phospholipase A2, group IIC | −1.08 | 10−4 | 0.05 |
| 29 | Lilrb3l | leukocyte immunoglobulin-like receptor, subfamily B, member 3-like | 7.34 | 10−4 | 0.05 |
| 30 | Hspa1b | heat shock protein family A (Hsp70) member 1B | −1.25 | 10−4 | 0.05 |
| 31 | Nmral1 | NmrA-like redox sensor 1 | 1.18 | 10−4 | 0.05 |
| 32 | Mogat2 | monoacylglycerol O-acyltransferase 2 | 2.08 | 10−4 | 0.05 |
| 33 | Defb17 | defensin β 17 | 6.02 | 10−4 | 0.05 |
| 34 | Sh3bgr | SH3 domain binding glutamate-rich protein | 1.11 | 10−4 | 0.05 |
| 35 | Eif2b3 | eukaryotic translation initiation factor 2B subunit γ | 0.63 | 10−4 | 0.05 |
| 36 | Fcrl2 | Fc receptor-like 2 | 1.12 | 10−4 | 0.05 |
| 37 | Fuca1 | α-L-fucosidase 1 | 1.10 | 10−4 | 0.05 |
| 38 | Bdh1 | 3-hydroxybutyrate dehydrogenase 1 | 0.37 | 10−4 | 0.05 |
| 39 | Rps16 | ribosomal protein S16 | 1.32 | 10−3 | 0.05 |
| 40 | Ifi27l2b | interferon-α-inducible protein 27 like 2B | 2.36 | 10−3 | 0.05 |
| 41 | Ifi47 | interferon-γ-inducible protein 47 | 1.47 | 10−3 | 0.05 |
| 42 | Mcm10 | minichromosome maintenance 10 replication initiation factor | −1.98 | 10−3 | 0.05 |
| 43 | Fjx1 | four-jointed box kinase 1 | 0.83 | 10−3 | 0.05 |
| 44 | Zmym6 | zinc finger MYM-type containing 6 | −0.59 | 10−3 | 0.05 |
| 45 | Use1 | unconventional SNARE in the ER 1 | 1.11 | 10−3 | 0.05 |
| 46 | Fus | FUS RNA-binding protein | 0.48 | 10−3 | 0.05 |
Note: log2, see the legend of Figure 1; p, the statistical significance according to Fisher’s Z-test without the Benjamini correction for multiple comparisons.