Table 4.
Coagulation parameters in neonatal and childhood vs. adult periods.
| Parameter | Neonatal Period (Mean Value) |
Normalization |
|---|---|---|
| Platelets | Normal or increased | 1 year (after transient increases) |
| von Willebrand factor (vWF) | Increased (153%) | 3 months |
| FII | Decreased (40–66%) | 1 year |
| FVII | Decreased (40–66%) | 1 year (up to 16 years) |
| FIX | Decreased (40–66%) | 1 year |
| FX | Decreased (40–66%) | 1 year |
| FXI | Decreased (37–54%) | 1 year |
| FXII | Decreased (37–54%) | 1 year |
| FV | Normal or decreased (70%) | 1 year (up to 16 years) |
| FVIII | Normal or increased (100%) | 1 month |
| Prekallikrein (PK) | Decreased (37–54%) | 1 year |
| High-molecular-weight kininogen (HMWK) | Decreased (37–54%) | 1 year |
| Fibrinogen | Decreased or normal | 1 year |
| Antithrombin (AT) | Decreased (63%) | 3 months |
| Protein C (PC) | Decreased (35%) | 16 years |
| Protein S (PS) | Decreased (36%) | 3 months |
| Plasminogen | Decreased (36%) | 6 months |
| Alpha 2 antiplasmin | Normal or decreased (85%) | 6 months |
| Tissue plasminogen activator (tPA) | Increased | 1 week |
| D-dimer | Increased | 16 years |
AT: antithrombin; HMWK: high-molecular-weight kininogen; PK: prekallikrein; PC: protein C; PS: protein S; tPA: tissue plasminogen activator; vWF: von Willebrand factor.