Table 5.

Main TEG®/ROTEM® results obtained in the healthy neonatal population: study characteristics.

Author	Included Neonates (n)	Control Group	Type of blood Sample	Analyzing Method	Findings
Wiegele et al. [56]	142 neonates. 55 preterm infants, 87 full-term infants		Cord blood	ROTEM	Significantly faster clot initiation and formation as well as higher clot strength in the term group
Schott et al. [58]	100 full-term neonates.50 delivered vaginally; 50 delivered by cesarean section		Cord blood	TEG	No differences between vaginal and cesarean delivery neonates in TEG measurements
Mirabella et al. [57]	85 full-term neonates	40 adults	Cord blood	TEG	No between neonatal and adult TEG parameters No differences between neonatal and adult TEG value ranges
Sidlik et al. [53]	101 neonates	Adults	Cord blood	ROTEM	Lower CT and CFT values and higher alpha angle in neonates (faster clot formation compared to adults). Accelerated fibrinolysis in the newborns compared to adults (shorter LI30)
Strauss et al. [54]	231 (84 full-term and 47 preterm infants)	Institution’s reference ranges for adults and children	Cord blood	ROTEM	CT and CFT significantly shorter among preterm and term infants compared to adults (faster clot formation) Decreased MCF in preterm compared to term neonates and adults. Correlation between GA and CT and MCF
Edwards et al. [52]	59 neonates (>34 weeks)	Institution’s reference ranges for adults and children	Cord blood	TEG	Accelerated initiation of coagulation and increased clot firmness and enhanced fibrinolytic activity compared to children (shorter R, higher angle, MA, CI, and G values) Accelerated initiation and propagation of coagulation compared to adults (shorter R, lower G values)
Cvirn et al. [55]	20 full-term neonates	20 adults	Cord blood	ROTEM	Lower MCF and α angle and longer CFT (FIBTEM) in neonates compared to adults