Table 6.
Main TEG®/ROTEM® results obtained in the sick neonatal population: study characteristics.
| Author | Included Neonates (n) |
Type of Blood Sample |
Analyzing Method |
Findings |
|---|---|---|---|---|
| Theodoraki et al. [65] | 215 full-term neonates | Whole blood | ROTEM | Positive correlation between LY30, LY45, and LY60 variables of EXTEM and INTEM assays and gestational age. ROTEM neonatal variables not influenced by maternal problems during pregnancy and delivery mode. Reduced A5 in INTEM and prolonged CT and CFT in INTEM and EXTEM assays were observed in neonates with higher hematocrit levels |
| Raffaeli et al. [94] | 60 neonates | Whole blood and cord blood | TEG | Placental blood leads to a procoagulant imbalance when testing is performed with TEG |
| Sokou et al. [63] | <37 weeks SGA: 22 <37 weeks AGA:25 ≥37 weeks SGA: 23 ≥37 weeks AGA: 23 |
Whole blood | ROTEM | No statistically significant differences were noticed regarding all EXTEM parameters between AGA and SGA neonates |
| Raffaeli et al. [95] | 283 neonates VLBW: 201, ≥37 weeks: 72 | Whole blood | TEG | Healthy VLBWIs showed TEG profiles suggesting a relatively balanced hemostatic system, with slight hypocoagulability initially (compared with term neonates), gradually evolving to a somewhat more procoagulant phenotype over the first month |
| Liu et al. [96] | 371 full-term neonates | Whole blood | TEG | Negative correlation between age and K value. Positive correlation between age and α angle, MA, LY30. Positive correlation between MA and birthweight. R value of females was higher than that of males and higher in cesarean section than that of spontaneous delivery |
| Sokou et al. [62] | 282 neonates. 198 term and 84 preterm |
Whole blood | ROTEM | Enhanced fibrinolytic activity in preterm neonates (LY60, significantly lower) |
| Sewell et al. [61] | 30 full-term neonates | Whole blood | TEG | Lower R and K values in neonates compared to older children. Higher fibrinolysis or rate of clot breakdown (LY30) and coagulation index (CI) in neonates compared to older children |
| Motta et al. [59] | 65 preterm neonates. <32 weeks: 32 32–37 weeks: 33 |
Whole blood | TEG | Increased fibrinolysis (higher LY30) in early preterm neonates compared to moderate/late preterm neonates |
| Ravn et al. [64] | 149 children. Neonates: 30 1–18 months: 72 19–72 months: 47 |
Whole blood | ROTEM | No sign of developmental changes in ROTEM assays, apart from CT in the EXTEM assay |
| Oswald et al. [97] | 51 infants (0–3 months) |
Whole blood | TEM | Subjects aged 0–3 months exhibited accelerated initiation and propagation of coagulation and maximum clot firmness |
| Kettner et al. [98] | 40 neonates. 27–31 weeks: 13, 32–36 weeks: 9, 36–40 weeks: 7, 34–40 weeks corrected: 11 |
Whole blood | TEG | When compared with the adult group, thromboelastography revealed no defects in coagulation from groups of clinically stable infants |
| Miller et al. [60] | 237 children Neonates: 37 |
Whole blood | TEG | Neonatal values did not statistically differ from those of older patients (aged from 1 to 24 months) |