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Chromosomal aberrations induced by 4 h exposure to furan in immortalized lymphoblastoid cell lines originated from a “normal” individual (LFA195+/+) or a patient with FA (LFA55−/−). (A) Treatments performed in the absence of S9 metabolic activation. (B) Treatments performed in the presence of S9 metabolic activation. Rat livers S9 tissue homogenates, prepared from animals induced with isoniazid to accumulate high levels of cytochrome P450 2-E1. ** p < 0.01.
