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. 2021 Sep 7;22(18):9687. doi: 10.3390/ijms22189687

Figure 5.

Figure 5

Chromosomal aberrations induced in the absence of S9 metabolism by BDA in immortalized lymphoblastoid cell lines originated from a normal individual (LFA195+/+) or from patients with FA (LFA55−/− or LFA145−/−) with different mutations in the FANCA gene (see M&M). (A) Treatments performed for 4 h and sampling of cells at 24 h from the beginning of treatment; (B) Treatments performed for 24 h and sampling of cells at 24 h from the beginning of treatment; (C) Treatments performed for 24 h with a recovery period of 12 h and sampling of cells at 36 h from the beginning of treatment in order to assess DNA repair in normal and FA lymphoblastoid cell lines. * p < 0.05; ** p < 0.01; *** p < 0.001.