Figure 8.

Induction of micronucleated binucleated cells and DNA 8-oxodG in the spleen of C57Bl6 and B6C3F1 following a 28-day oral exposure to furan. Frequency of Bin/Min/1000 splenocytes induced in C57Bl6 mice following exposure to the indicated furan doses (A); Levels of 8-oxodG/residues/10⁶ dG in spleen DNA from furan-treated C57Bl6 (B) and B6C3F1 mice (C); Frequency of MnBn/1000 splenocytes in furan treated C57Bl6 mice (hatched bars) are taken from Leopardi et al., 2010 (D); Frequency of MnBn/1000 splenocytes in furan treated C57Bl6 mice (open bars) and Ogg1^−/− mice (closed bars) (E). All values are mean +/− SE (5–11 animals/group). Asterisks indicate significant differences (** p < 0.01, *** p < 0.001 by two-tailed Student’s t-test), ns, not significant; MnBn, Micronucleated binucleatedcells.