Table 1.
Tk+/Tk− mutations induced by 24 h exposure to furan in L5178Y cells.
| Dose (mM) |
RTG (%) |
MF (×10−6 Cells) |
Induced MF (×10−6 Cells) |
Small Colonies MF (×10−6 Cells) |
Large Colonies MF (×10−6 Cells) |
Small/Large Colonies (%) |
|---|---|---|---|---|---|---|
| 0 | 100 | 90.7 | - | 38.4 | 48.9 | 0.44 |
| 1.78 | 109 | 70.6 | 0 | 32.0 | 41.1 | 0.44 |
| 2.37 | 133 | 74.2 | 0 | 28.3 | 40.7 | 0.41 |
| 3.13 | 125 | 61.7 | 0 | 15.2 | 40.8 | 0.27 |
| 4.22 | 97 | 72.3 | 0 | 30.5 | 38.6 | 0.44 |
| 5.62 | 96 | 76.1 | 0 | 29.2 | 42.9 | 0.41 |
| 7.50 § | 3 | 294.5 | 203.8 | 182.3 | 94.7 | 0.66 |
| Linear trend | NS | NS | NS | |||
| MMS 45.4 × 10−3 |
125 | 344.1 ** | 253.4 | 154.5 ** | 131.3 ** | 0.54 |
| 0 | 100 | 66.8 | - | 14.4 | 50.6 | 0.22 |
| 3.06 | 82 | 55.6 | 0 | 15.4 | 38.7 | 0.28 |
| 3.35 | 70 | 74.5 | 7.71 | 16.1 | 56.0 | 0.22 |
| 3.67 | 51 | 75.0 | 8.24 | 18.4 | 54.7 | 0.25 |
| 4.03 | 46 | 80.4 | 13.60 | 28.4 | 49.5 | 0.36 |
| 4.42 | 50 | 103.4 | 36.62 | 27.5 | 72.3 | 0.28 |
| 4.84 | 24 | 113.2 | 46.43 | 32.2 | 77.5 | 0.29 |
| 5.31 § | 11 | 145.0 | 78.16 | 65.1 | 71.2 | 0.48 |
| 5.82 § | 8 | 127.5 | 60.68 | 51.4 | 70.0 | 0.42 |
| Linear trend | * p < 0.05 | * p < 0.05 | NS | |||
| MMS 45.4 × 10−3 |
125 | 424.4 ** | 357.6 | 119.2 ** | 242.4 ** | 0.54 |
§ Treatment excluded from statistical analysis due to extreme cytotoxicity; * p < 0.05; ** p < 0.01; RTG, Relative Total Growth; MF, Mutation Frequency; MMS, Methyl methanesulfonate.