Table 5.
Cytogenetic analysis of cytokinesis-blocked splenocytes of C57Bl6 mice following 4-week exposure to furan.
| MnBn | ||||
|---|---|---|---|---|
| Furan Dose | Mice | MnBn/1000 Cells | Frequency | |
| mg/kg bw | No. | Individual Animal Data | Group Mean ± SE | |
| Exp. 1 | 0 | 5 | 5, 3, 2, 5, 1 | 3.2 ± 0.8 |
| 8 | 5 | 6, 1, 9, 8, 8 | 6.4 ± 1.4 | |
| 15 | 5 | 8, 9, 6, 3, 7 | 6.6 * ± 1.1 | |
| 30 | 6 | 7, 16, 7,10, 6, 9 | 9.2 ** ± 1.5 | |
| Exp. 2 | 0 | 6 | 2, 4, 2, 1, 3, 2 | 4.6 ± 0.8 |
| 8 | 6 | 1, 3, 5, 3, 7, 4 | 7.6 ± 0.4 | |
| 15 | 6 | 6, 3, 3,4, 7, 3 | 8.6 * ± 1.1 | |
| 30 | 5 | 12, 5, 10, 8, 9 | 17.6 ** ± 1.5 | |
* p < 0.05; ** p < 0.001 (Student t test); MnBn, Micronucleated binucleated cells.