Figure 3.

(A) Scheme on designing p-aminophenyl-α-D-mannopyranoside (MAN)-conjugated nanoliposome (LIP) drug delivery vehicles (MAN-LIP). (B) In vivo time-dependent images of mice after intravenous injection (LIP and MAN-LIP are DiR labeled) of each preparation. MAN-LIP + phenobarbital-represented mice were anaesthetized with phenobarbital (80 mg/kg) following DiR-labeled MAN-LIP. (C) The major regions of brain were given as: Cx, cerebral cortex; T, thalamus; Cb, cerebellum; Mb, midbrain; P, pons; Md, medulla; Ht, hypothalamus. (D) Ex vivo images of sagittal mice brain sections after intravenous injection of each preparation. (B,D) The different pseudo colors in the photographs corresponded to the intensity of fluorescence signals. The autofluorescence of the controls was subtracted as the background (reprinted with permission [76]).