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(A). The mechanism on lactoferrin (Lf)-tagged magnetic nanoparticles crossing the BBB via injection into the bloodstream. (B). Axial T2* images of rat brains captured pre injection and 15 min post injection of Fe3O4-Lf (b,d) and Fe3O4 (a,c), respectively. The higher contrast of brain blood vessels by the Fe3O4-Lf probe is highlighted by red dashed-line circles (reprinted with permission from [119]).
