Table 1.
Baseline characteristics of study participants.
| Parameter | Overall | 7-Day TIR70–180 in ≥50% of Readings | 7-Day TIR70–180 in <50% of Readings | p Value |
|---|---|---|---|---|
| Number of patients | 37 | 26 | 11 | - |
| Age (years) | 62.0 ± 17.3 | 64.7 ± 16.6 | 55.6 ± 17.8 | 0.16 |
| Male gender (n, %) | 20 (54.1%) | 14 (53.8%) | 6 (54.5%) | >0.90 |
| BMI (kg/m2) | 26.8 ± 4.1 | 26.2 ± 2.7 | 28.5 ± 6.2 | 0.11 |
| Dialysis vintage (months) | 27 (3, 160) | 27 (3, 120) | 24 (3, 160) | 0.57 |
| History of hypertension (n, %) | 37 (100%) | 26 (100%) | 11 (100%) | - |
| History of dyslipidemia (n, %) | 26 (70.3%) | 17 (65.4%) | 9 (81.8%) | 0.44 |
| History of CAD (n, %) | 23 (62.2%) | 16 (61.5%) | 7 (63.6%) | >0.90 |
| History of CHF (n, %) | 17 (45.9%) | 14 (53.8%) | (3 (27.3%) | 0.17 |
| Hemoglobin (g/dL) | 10.9 ± 1.2 | 11.0 ± 1.1 | 10.7 ± 1.5 | 0.49 |
| Predialysis urea (mg/dL) | 139.6 ± 32.2 | 146.3 ± 33.1 | 124.0 ± 24.7 | <0.05 |
| Predialysis creatinine (mg/dL) | 7.1 ± 2.7 | 7.4 ± 2.7 | 6.4 ± 2.6 | 0.33 |
| Predialysis glucose (mg/dL) | 164.2 ± 67.4 | 149.4 ± 39.8 | 199.2 ± 102.3 | <0.05 |
| Serum albumin (g/dL) | 3.9 ± 0.5 | 3.9 ± 0.5 | 4.0 ± 0.3 | 0.61 |
| HbA1c (%) | 6.5 ± 1.4 | 6.3 ± 1.4 | 7.1 ± 1.3 | 0.10 |
| Glycated albumin (%) | 17.1 ± 5.2 | 15.0 ± 4.1 | 21.9 ± 4.6 | <0.001 |
| Mean 7-day CGM-derived glucose (mg/dL) | 162.1 ± 38.1 | 148.9 ± 24.4 | 193.3 ± 47.1 | <0.001 |
| 7-day CGM-derived CV (%) | 29.5 ± 6.5 | 28.5 ± 6.8 | 31.9 ± 5.0 | 0.09 |
| 7-day CGM-derived TIR70–180 (% of readings) | 64.5 ± 21.5 | 74.9 ± 15.5 | 39.7 ± 10.0 | <0.001 |
| 7-day CGM-derived TBR<70 (% of readings) | 3.6 (0, 65.8) | 2.5 (0, 17.4) | 6.4 (0, 65.8) | 0.33 |
| 7-day CGM-derived TAR>250 (% of readings) | 9.2 (0, 52.1) | 4.0 (0, 27.6) | 21.3 (0, 52.1) | <0.001 |
| Insulin therapy (n, %) | 37 (100%) | 26 (100%) | 11 (100%) | - |
| Oral anti-diabetic medication use (n, %) | 0 (0%) | 0 (0%) | 0 (0%) | - |
Abbreviations: BMI = body mass index; CAD = coronary artery disease; CGM = continuous glucose monitoring; CHF = congestive heart failure; CV = coefficient of variation; HbA1c = glycated hemoglobin A1c; TAR = time above target glucose range; TBR = time below target glucose range; TIR = time in target glucose range.