Figure 1.
Historical Timelines of Endocrine FGFs. Historical perspective of notable events in the discovery and development of endocrine FGFs. (Panel-A): FGF19 timeline from discovery to the most recent clinical trial for FGF19-based biomedical application, aldafermin. (Panel-B): FGF21 timeline from discovery to the most recent findings pertaining to the structure of FGF21. (Panel-C): FGF23 timeline from discovery to the most recent findings regarding its therapeutic role in treating acute inflammation.