Figure 1.

CRC-PDE area and concentration. (a) Measurement of CRC-PDE area after tumour sample processing (day 0); box-and-whisker plot shows the median (middle lines), interquartile range (boxes) and minimum to maximum values (whiskers); data were calculated from measurements of at least 15 explants. (b) CRC-PDE area and (c) CRC-PDE concentration, along 4 weeks of culture; data are presented as mean ± SD, calculated from at least seven biological replicates; statistical significance was evaluated by a mixed effects model for analysis of repeated measurements followed by post-hoc Dunnett’s test comparing with day 0; * p < 0.05, ** p < 0.01. CRC-PDE, colorectal cancer patient-derived explants.