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Cytotoxic mechanisms of peripheral blood mononuclear cells (PBMCs) investigated with TiO2 NPs (b). TEM images of apoptosis (a) and necrosis (c) of PBMCs. (COX-2 = cyclooxygenase-2; IL = interleukin; and TNF = tumor necrosis factor). Adapted with permission from [10]. Copyright, 2016 John Wiley & Sons, Inc.
