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. 2021 Sep 15;13(9):1164–1183. doi: 10.4251/wjgo.v13.i9.1164

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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/

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Protein-protein interaction network of the 83 predicted targets and scoparone inhibits proliferation. A: Protein-protein interaction (PPI) network of the 83 predicted targets through STRING; B: Visualized PPI network of the 83 predicted targets through Cytoscape 3.7.2. Darker nodes indicate higher degree value; C: Expression patterns of the following candidate hub genes: AKT1, MAPK8, and EGFR; the red represents the tumor group and the gray represents the normal group; D and E: IC₅₀ values of scoparone for Capan-2 and SW1990 cells shown by CCK-8 assay; F and G: Scoparone inhibits the proliferation of Capan-2 and SW1990 cells. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001, ^dP < 0.0001 vs the control group.