Table 1.
Details of the articles retrieved from the searches
|
Ref.
|
Study type
|
Type of hyperthermia
|
Tumor type
|
| Falk et al[22], 19861 | nRCT | Regional | PC |
| Kim et al[37], 1989 | pOS | Regional | HCC |
| Kakehi et al[23], 19901 | RCT | Regional | Mixed, incl. HCC and PC |
| Nagata et al[63], 1990 | pOS | Regional | Mixed, incl. HCC and CCC |
| Akuta et al[66], 1991 | pOS | Regional | Mixed, incl. HCC |
| Hamazoe et al[51], 1991 | pOS | Regional | Mixed, incl. HCC, PC and BC |
| Maeda et al[69], 1991 | CR | Regional | HCC |
| Seong et al[65], 1991 | CR | Regional | HCC |
| Yumoto et al[38], 19911 | RCT | Regional | HCC |
| Kim et al[39], 1992 | nRCT | Regional | HCC |
| Tanaka et al[64], 1992 | pOS | Regional | Mixed, incl. HCC and CCC |
| Robins et al[25], 1993 | nRCT | Whole-body | Mixed, incl. PC |
| Maeta et al[67], 1994 | rOS | Regional | Mixed, incl. HCC |
| Seong et al[40], 1994 | pOS | Regional | HCC |
| Nagata et al[41], 1997 | pOS | Regional | Mixed, incl. HCC and CCC |
| Robins et al[26], 1997 | nRCT | Whole-body | Mixed, incl. HCC and PC |
| Dvorák et al[68], 2002 | CR | Regional | HCC |
| Kamisawa et al[74], 2005 | pOS | Regional | BC |
| Ostapenko et al[72], 20051 | pOS | Regional | HCC |
| Mambrini et al[45], 2007 | pOS | Regional | BC, incl. CCC and GC |
| Bull et al[27], 2008 | pOS | Whole-body | Mixed, incl. PC |
| Cho et al[29], 2008 | pOS | Regional | Mixed, incl. PC |
| Ishikawa et al[52], 2008 | rOS | Regional | PC |
| Ohguri et al[31], 20081 | rOS | Regional | PC |
| Zhang et al[30], 2008 | pOS | Regional | PC |
| Bakshandeh-Bath et al[28], 2009 | pOS | Whole-body | PC |
| Maluta et al[53], 20111 | pOS | Regional | PC |
| Dani et al[58], 2012 | rOS | mEHT | PC |
| Ishikawa et al[47], 20121 | nRCT | Regional | PC |
| Tschoep-Lechner et al[33], 2013 | rOS | Regional | PC |
| Wang et al[73], 2013 | pOS | Regional | HCC |
| Gadaleta-Caldarola et al[42], 2014 | pOS | mEHT | HCC |
| Volovat et al[32], 2014 | pOS | Regional | PC |
| Chen et al[46], 2016 | rOS | Regional | CCC |
| Dong et al[20], 20161 | RCT | Regional | HCC |
| Yu et al[43,44], 2016, 20171 | nRCT | Regional | HCC |
| Datta et al[62], 2017 | RCT | Regional | PC |
| Fan et al[34], 2017 | rOS | Regional | PC |
| Maebayashi et al[54], 2017 | rOS | Regional | PC |
| Pang et al[59], 2017 | RCT | mEHT | Mixed, incl. HCC and PC |
| Bonucci et al[57], 2018 | CR | Regional | PC |
| Ryu et al[75], 2018 | CR | Regional | CCC |
| Werthmann et al[56], 2018 | CR | Regional | PC |
| Fiorentini et al[36], 2019 | rOS | mEHT | PC |
| He et al[35], 2019 | rOS | Regional | PC |
| Iyikesici et al[55], 2020 | rOS | Regional | PC |
Most subjects included in the studies were patients with advanced or metastatic malignancies with no probability of cure with conventional treatments (Stage III and IV).
1
Study including some Stage I and II patients. BC: Biliary cancer; CCC: Cholangiocellular cancer; CR: Case report; GC: Gallbladder cancer; HCC: Hepatocellular cancer; mEHT: Modulated electrohyperthermia; nRCT: Non-randomized clinical trial; PC: Pancreatic cancer; pOS: Prospective observational study; RCT: Randomized clinical trial; rOS: Retrospective observational study.