Table 1.

Potential advantages and disadvantages of neoadjuvant chemotherapy for colorectal liver metastases

Advantages	Disadvantages
(1) Conversion to resectability	(1) Chemotherapy-associated liver injury
(2) Facilitate parenchymal-sparing or minimally invasive approach	(2) Local progression that precludes hepatic resection (rare)
(3) Higher rates of negative margins	(3) Disappearing liver metastases
(4) Improved patient selection for surgery	(4) Toxicity from chemotherapy
(5) Improved rates of multimodality therapy
(6) Early treatment of micro-metastases
(7) Ability to assess response to therapy