Table 3.
Effects of metolazone plus furosemide (Group M) vs. furosemide alone (Group F) administration on renal function electrolyte balance and saline solution. Metolazone addition showed significant weight loss and less oral loop diuretic amount at discharge.
| GROUP F | GROUP M | ||
|---|---|---|---|
| Blood Urea (mg/dL) | 82 ± 40 [median 76 IQR 58–95] | 66 ± 18 [median 67 IQR 52–75] | p = 0.005 |
| Mean eGFR (mL/min/m2) | 36.8 ± 22 [median 38 IQR 25–52] | 38.5 ± 24 [median 39 IQR 26–50] | 0.8 |
| CREATININE (mg/dL) | 1.69 ± 0.62 [median 1.5 IQR 1.3–2.2] | 1.72 ± 0.78 [median 1.5 IQR 1.2–2.1] | 0.5 |
| K+ DISCHARGE (mEq/L) | 3.87 ± 0.55 [median 3.9 IQR 3.7–4.4] | 4.05 ± 0.67 [median 4.1 IQR 3.6–4.2] | 0.4 |
| NA+ DISCHARGE (mEq/L) | 138.6 ± 4.45 [median 138 IQR 135–141] | 137.8 ± 4.3 [median 138 IQR 135–141] | 0.6 |
| HYPERTONIC SOLUTION | 8 (12%) | 22 (33%) | p = 0.03 |
| MEAN DIURESIS (mL) | 2050 ± 1120 [median 2080 IQR 1650–2800] | 2820 ± 900 [median 2450 IQR 1900–3000] | p < 0.05 |
| Δ WEIGHT (kg) | −3 ± 1.5 | −6 ± 2.3 | p < 0.01 |
| LOOP DIURETIC DOSE AT DISCHARGE (mg) | 223.9 ± 121.7 [median 175 IQR 125–275] | 175 ± 104.8 [median 150 IQR 100–250] | p < 0.05 |