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. 2021 Sep 17;10(9):2459. doi: 10.3390/cells10092459

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Basic characteristics of the training paradigm. Mice were subjected to 13 weeks of weighted pulling (WP) and, during each training session, various parameters were measured including: (A) the number of sets that were successfully completed; (B) the maximal load that was successfully pulled the entire length of the lane; (C) the number of times the rear was touched; and (D) the number of shocks that were delivered. Individual data points are indicated with hollow symbols and weekly means for the entire group are indicated with solid symbols. The group data are presented as the mean ± SD (n = 10/group). All datasets were analyzed with repeated measures one-way ANOVA. Multiple pairwise comparisons were FDR corrected with the two-stage step-up method of Benjamini, Krieger, and Yekutieli and the detailed outcomes of these analyses can be found in the Supplemental Statistical Summary Document.