Figure 1.

Schematic illustrating the regulation of biomolecular condensates by melatonin represented through observations reported in antioxidant protection against lipid peroxidation to maintain membrane/lipid raft composition/stability that serves to maintain adequate ATP levels in all cellular compartments to fuel, support, and regulate post-translational/m⁶A modifications that may fine-tune RNA dynamics in the assembly and disassembly of MLOs to prevent pathological aggregations in neurodegenerative disorders. LLPS: liquid–liquid phase separation; DDX: Dead-box RNA helicase; m6A: N⁶-methyladenosine; MLO: membraneless organelle; RBP: RNA-binding protein; RNP: ribonucleoprotein; PTM: post-translational modification (See Abbreviations for additional acronyms).