Figure 2.

Illustrating the inhibition of transcription factors activated in cancer through cardiac glycosides. The binding of CGs on the Na⁺/K⁺/ATPase (NKA) channel decreases the NKA pump activity and thus down regulates multiple signal transduction cascades especially targeting the TF proteins involved in the cell growth and cell proliferation by providing signals to the transcription machinery. Dysregulated TF and their targeted therapy through CG are represented in the pathway. The scope of targeting nuclear receptors via CG is an upcoming purview to be studied for therapeutic potential.