Table 1.
Sample | Diameter | ζ Potential (mV) | PDI | Encapsulation Efficiency (% w/w) | |||
---|---|---|---|---|---|---|---|
NIR | poly(I:C) | R848 | MIP3α | ||||
NP(NIR + pIC + R848 + MIP3α)-PEG | 249.6 ± 85.4 | −21.4 ± 4.75 | 0.178 ± 0.042 | 62.4 ± 6.9 | 43.6 ± 8.6 | 54.2 ± 8.9 | 59.3 ± 7.3 |
Physicochemical characterization of the PLGA-PEG NPs containing immunostimulatory agents. The PLGA NPs were characterized as reported previously [20], by dynamic light scattering and zeta potential measurements. The size and zeta potential data represent the mean value ± SD of 10 readings of one representative batch. The concentration of the NIR dye was measured by fluorescence. The concentration of poly(I:C), R848, and MIP3α was determined by RP-HPLC analysis.