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. 2021 Sep 13;13(18):4597. doi: 10.3390/cancers13184597

Figure 3.

Figure 3

Summary of the CNA patterns on chromosome 12 in four cases with two non-identical der(12)t(12;21) (#1–4) copies and one with a der(21)t(12;21) (#5). The corresponding case numbers are shown on the left and the location of the ETV6 gene is marked with a red box in the gene track. The rearrangements in the ETV6-surrounding region are far more complex than those in the RUNX1-surrounding one and essentially reflect the difficulties that accompany the successful fusion of the reversely orientated RUNX1 and ETV6 genes. In the four cases with a der(12), the telomeric part (including ETV6) of the second chromosome 12 is deleted. The CN-LOH regions of the adjacent extended ETV6-containing centromeric part of both homologues in three of them provide convincing evidence that these complex configurations must be produced simultaneously in a single step [32].