Table 2.
Efficacy of LDV/SOF treatment in 37 adolescents with CHC (intention-to-treat and per-protocol analysis).
| Patient Characteristics | Number | SVR12 (ITT) | SVR12 (PP) | |
|---|---|---|---|---|
| Overall | 36/37 | 97% | 100% | |
| HCV genotype | 1 | 31/32 | 97% | 100% |
| 4 | 5/5 | 100% | 100% | |
| Baseline liver fibrosis (METAVIR) | F0/1 | 33/33 | 100% | 100% |
| F ≥ 2 | 3/4 | 75% | 100% | |
| Duration of LDV/SOF treatment | 12 weeks | 35/35 | 100% | 100% |
| 24 weeks | 1/2 | 50% | 100% | |
| Previous ineffective treatment with interferon and ribavirin | Yes | 13/14 | 93% | 100% |
| No | 23/23 | 100% | 100% | |
ITT—intention-to-treat; PP—per-protocol analysis; SVR12—sustained virological response.