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. 2021 Sep 8;10(9):2359. doi: 10.3390/cells10092359

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Dietary glucose decreases lifespan by altering cellular localization of several transcriptional factors. High glucose, probably through activation of the IIS pathway, diminishes the nuclear localization and transcriptional activity of DAF-16/FOXO and SKN-1, which consequently decreases the worms’ lifespan. Interestingly, high glucose augments the nuclear localization of HLH-30 and SBP-1/MDT-15, although with opposite consequences, because HLH-30 decreases the lifespan whereas SBP-1/MDT-15 prevents the life-shortening effects of high glucose.