Table 3.

Univariable and multivariable cox regression for analyzing the prognostic factors for esophageal cancer patients with brain metastases

Subject characteristics	Univariable		Multivariable
	HR (95% CI)	P-value	HR (95% CI)	P-value
Age (years)
< 65	1 (reference)		1 (reference)
> =65	0.90 (0.66–1.22)	0.499
Sex
Male	1 (reference)		1 (reference)
Female	1.01 (0.63–1.63)	0.967
Race
White	1 (reference)		1 (reference)
Black	1.84 (0.75–4.52)	0.184
Asian or Pacific Islander	1.63 (0.80–3.32)	0.182
American Indian/Alaska Native	1.39 (0.51–3.77)	0.516
Primary site
Upper third	1 (reference)		1 (reference)
Middle third	1.45 (0.34–6.13)	0.611
Lower third	1.14 (0.28–4.60)	0.857
Overlapping lesion	1.69 (0.39–7.32)	0.484
Histology
Esophageal squamous cell carcinoma	1 (reference)		1 (reference)
Esophageal adenocarcinoma	0.60 (0.40–0.90)	0.013	0.84 (0.55–1.29)	0.427
Grade
Grade I	1 (reference)		1 (reference)
Grade II	0.52 (0.25–1.11)	0.09
Grade III	0.73 (0.36–1.51)	0.398
Grade IV	0.39 (0.10–1.49)	0.169
T stage
T1	1 (reference)		1 (reference)
T2	0.38 (0.21–0.68)	0.001	0.36 (0.20–0.65)	< 0.001
T3	0.63 (0.43–0.94)	0.023	0.66 (0.44–0.99)	0.047
T4	1.16 (0.80–1.68)	0.438	1.21 (0.82–1.78)	0.335
N stage
N0	1 (reference)		1 (reference)
N1	0.70 (0.48–1.03)	0.073
N2	0.67 (0.37–1.21)	0.183
N3	0.90 (0.47–1.70)	0.74
Bone metastases
None	1 (reference)		1 (reference)
Yes	2.04 (1.45–2.87)	< 0.001	1.95 (1.34–2.83)	< 0.001
Liver metastases
None	1 (reference)		1 (reference)
Yes	1.49 (1.08–2.05)	0.015	1.23 (0.87–1.74)	0.239
Lung metastases
None	1 (reference)		1 (reference)
Yes	1.92 (1.38–2.67)	< 0.001	1.49 (1.03–2.16)	0.035