Table 4.
Serum adipokines and markers of inflammation before and after 3 month dietary intervention.
| Group | Time | Leptin (ng/mL) |
Adiponectin (µg/mL) |
Resistin (ng/mL) | Visfatin (ng/mL) | IL-6 (pg/mL) | CRP (mg/L) |
sE-Selectin (pg/mL) |
MCP-1 (pg/mL) |
sPECAM-1 (ng/mL) |
sVCAM-1 (ng/mL) |
|---|---|---|---|---|---|---|---|---|---|---|---|
| IS + placebo (n = 14) |
Baseline | 26.86 ± 16.90 | 6.37 ± 4.21 | 9.42 ± 3.81 | 1.14 ± 0.35 | 1.67 ± 1.02 | 2.12 ± 2.18 | 45.13 ± 10.64 | 411 ± 95 | 73.73 ± 15.59 | 558.3 ± 132.3 |
| After 3 months | 24.67 ± 15.95 | 5.92 ± 4.20 | 10.04 ± 3.70 | 1.07 ± 0.61 | 1.24 ± 0.49 | 1.62 ± 1.29 | 43.12 ± 11.42 | 374 ± 79 | 65.59 ± 16.53 | 544.3 ± 122.4 | |
| IS + n-3 PUFA (n = 13) |
Baseline | 23.62 ± 13.61 | 6.59 ± 2.35 | 9.01 ± 2.15 | 0.95 ± 0.61 | 0.95 ± 0.44 | 1.51 ± 1.19 | 31.81 ± 12.69 | 302 ± 60 | 69.93 ± 13.63 | 586.8 ± 123.7 |
| After 3 months | 21.71 ± 13.06 | 6.49 ± 2.36 | 9.08 ± 2.25 | 0.76 ± 0.39 | 0.84 ± 0.38 | 1.35 ± 1.02 | 31.05 ± 12.49 | 282 ± 60 | 63.86 ± 17.41 | 569.2 ± 124.2 | |
| CR + placebo (n = 14) |
Baseline | 42.12 ± 21.68 | 4.96 ± 2.48 | 9.26 ± 3.08 | 1.12 ± 0.67 | 1.75 ± 0.93 | 3.35 ± 2.41 | 37.66 ± 12.70 | 337 ± 66 | 71.01 ± 18.41 | 581.9 ± 167.7 |
| After 3 months | 34.69 ± 23.31 | 5.43 ± 3.20 | 9.50 ± 3.12 | 0.92 ± 0.68 | 1.38 ± 0.72 | 2.36 ± 1.55 | 30.52 ± 10.56 | 324 ± 60 | 63.15 ± 15.12 | 594.5 ± 174.7 | |
| CR + n-3 PUFA (n = 23) |
Baseline | 30.61 ± 27.48 | 5.56 ± 2.87 | 9.96 ± 3.34 | 1.33 ± 0.98 | 1.49 ± 1.35 | 2.62 ± 2.25 | 40.35 ± 18.92 | 357 ± 109 | 65.08 ± 14.33 | 618.5 ± 139.0 |
| After 3 months | 21.89 ± 16.51 | 5.87 ± 2.51 | 10.42 ± 3.02 | 1.27 ± 1.23 | 1.25 ± 0.66 | 1.52 ± 1.50 | 36.23 ± 16.18 | 337 ± 105 | 60.64 ± 13.52 | 606.9 ± 130.7 | |
| p-Value time x diet | 0.054 | 0.008 | 0.998 | 0.316 | 0.857 | 0.324 | 0.010 | 0.435 | 0.662 | 0.306 | |
| p-Value time x supplementation | 0.908 | 0.385 | 0.715 | 0.442 | 0.318 | 0.764 | 0.187 | 0.992 | 0.206 | 0.433 | |
| p-Value time x diet x suplementation | 0.699 | 0.580 | 0.367 | 0.359 | 0.846 | 0.410 | 0.580 | 0.580 | 0.754 | 0.617 | |
Values are presented as means ± SD. Statistics: analyses were performed with repeated-measures by ANOVA. Abbreviations: CR, caloric restriction; CRP, C-reactive protein; MCP-1, monocyte chemoattractant protein 1; IL-6, interleukin 6; IS, isocaloric diet; sPECAM-1, soluble platelet endothelial cell adhesion molecule 1; and sVCAM-1, soluble vascular cell adhesion protein 1.