Table 1.

A list of the metabolites determined in the serum of patients and identified as significantly different between the analyzed groups based on either analysis of variance (ANOVA) or non-parametric Kruskal–Wallis ANOVA, depending on the normality of distribution and the variance equality. All values are expressed in micromoles.

Serum
No.	Metabolite	Control (n = 10)			PD (n = 11)			APDs (n = 8)
		Mean	SD	Median	Mean	SD	Median	Mean	SD	Median
1	C18:2	0.04	0.01	0.04	0.05	0.01	0.05	0.05	0.01	0.05
2	Ornithine	86.43	20.57	88.30	114.47	32.3	112.00	105.91	15.63	105.50
3	Tyrosine	61.88	12.51	57.80	86.95	25.96	82.5	90.75	38.16	80.55
4	Putrescine	0.11	0.03	0.11	0.20	0.06	0.21	0.25	0.14	0.21
5	Spermidine	0.14	0.04	0.14	0.20	0.04	0.19	0.23	0.05	0.23
6	t4-OH-Proline	7.96	1.41	7.80	18.95	23.11	13.30	15.29	4.78	13.55
7	Total DMA	0.68	0.13	0.65	0.79	0.14	0.83	0.95	0.14	0.95
8	lysoPC a C26:0	0.31	0.14	0.28	0.48	0.19	0.38	0.30	0.08	0.31
9	lysoPC a C28:0	0.35	0.17	0.30	0.47	0.1	0.48	0.30	0.09	0.27
10	lysoPC a C28:1	0.47	0.18	0.45	0.67	0.21	0.62	0.50	0.13	0.456
11	PC aa C34:4	1.62	0.67	1.62	1.85	0.68	1.85	1.08	0.31	0.97
12	PC aa C38:1	1.19	0.51	1.20	0.99	0.38	0.94	0.53	0.29	0.63
13	PC ae C36:4	18.87	5.01	19.10	16.27	3.25	15.60	11.45	3.81	10.34
14	PC ae C38:4	14.38	3.23	14.05	13.75	2.41	13.20	10.91	2.52	10.70
15	PC ae C38:5	17.87	4.07	17.80	16.29	2.37	17.00	12.46	3.13	11.75
16	PC ae C40:1	1.31	0.30	1.31	1.33	0.27	1.25	1.03	0.18	1.06
17	PC ae C42:1	0.31	0.088	0.31	0.37	0.06	0.37	0.29	0.07	0.28
18	PC ae C42:4	0.68	0.27	0.77	0.65	0.25	0.67	0.39	0.22	0.39

PD—Parkinson’s disease; APDs—atypical parkinsonian disorders; DMA—dimethylarginine; C18:2—octadecadienylcarnitine; PC aa/ae C X:Y—diacyl(aa)/acyl-alkyl (ae) phosphatidylcholine with the total number of carbon atoms denoted by X and the number of double bonds indicated by Y.