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Surface DNA. Little is known about DNA interaction with circulating tumor cells (CTCs) or extracellular vesicles (EVs). (A) Neutrophils travel with CTC clusters in the bloodstream; this interaction might be facilitated by netosis with the formation of neutrophil extracellular traps (NETs) of DNA expelled from the neutrophil nucleus. (B) DNA may be present on the EV surface; however, few studies have been performed to understand this phenomenon.
