Table 3. Univariate Cox regression analysis for TCGA cohort.

T stage, N stage, Stage and Risk group were significantly associated with OS.

Variables		Number (percent)	HR(95CI)	P-Value
Age				0.370
	<65y	136 (42.9%)	reference
	≥65y	181 (57.1%)	1.18 (0.82–1.70)	0.372
Gender				0.455
	Female	163 (51.4%)	reference
	Male	154 (48.6%)	1.14 (0.80–1.62)	0.455
Tstage				<0.001
	T1	98 (30.9%)	reference
	T2	180 (56.8%)	2.0 (1.23–3.23)	0.005
	T3+4	39 (12.3%)	4.02 (2.23–7.23)	<0.001
Nstage				<0.001
	N0	203 (64.0%)	reference
	N1	67 (21.1%)	2.028 (1.33–3.09)	<0.001
	N2	47 (14.8%)	3.342 (2.16–5.18)	<0.001
Stage				<0.001
	I	172 (54.3%)	reference
	II	86 (27.1%)	1.77 (1.16–2.70)	<0.001
	III	59 (18.6%)	3.44 (2.25–5.28)	<0.001
Risk_group				<0.001
	Low-risk	159 (50.2%)	reference
	High-risk	158 (49.8%)	2.727 (1.87–3.98)	<0.001